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Séminaire Chimie ED459/28 Mars 2019 à 14h

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Metal complexes in medicinal chemistry

Prof. Gilles Gasser (Laboratory for Inorganic Chemical Biology, i-CLeHS Institute of Chemistry for Life and Health Sciences, FRE 2027, CNRS, ENSCP Chimie ParisTech)

Le Jeudi 28 Mars 2019 à 14h ENSCM, Amphithéâtre Mousseron A (campus Balard, 240 av. Émile-Jeanbrau)

Metal complexes are currently playing a tremendous role in medicine. For example, the platinum complex cisplatin and its derivatives oxaliplatin and carboplatin are employed in more than 50% of the treatment regimes for patients suffering from cancer !

Over the last years, our research group focused its attention on the development of novel metal complexes as imaging and therapeutic agents against cancer and parasitic diseases.[1-6] During this talk, we will present our latest results, including in vivo results, on these topics. References

1. F. W. Heinemann, J. Karges, G. Gasser, Acc. Chem. Res. 2017, 50, 2727–2736. 2. M. Patra, G. Gasser, Nature Rev. Chem. 2017, 1, 0066, and references therein. 3. A. Notaro, G. Gasser, Chem. Soc. Rev. 2017, 46, 7317–7337. 4. M. Patra, K. Zarschler, H.-J. Pietzsch, H. Stephan, G. Gasser, Chem. Soc. Rev. 2016, 45, 6415–6431. 5. Y. C. Ong, S. Roy, P. C. Andrews, G. Gasser, Chem. Rev. 2019, 119, 730–796. 6. M. Brandt, J. Cardinale, M. L. Aulsebrook, G. Gasser, T. L. Mindt, J. Nucl. Med. 2018, 59, 1500–1506.

Contact local IBMM : Dr. Xavier Bantreil (DAPP) xavier.bantreil@umontpellier.fr|